Novel enhancers of guanylyl cyclase-A activity via allosteric modulation.
Henriette AndresenCristina Pérez-TerneroJerid RobinsonDeborah M DickeyAdrian J HobbsLincoln R PotterFinn Olav LevyAlessandro CataliottiLise Román MoltzauPublished in: British journal of pharmacology (2023)
We describe a novel allosteric binding site on GC-A, which can be targeted by small molecules that enhance ANP and BNP effects. These compounds will be valuable tools in further development and proof-of-concept of GC-A enhancement for the potential use in cardiovascular therapy.