Imaging and genetics in Parkinson's disease: assessment of the GBA1 mutation.

Sweta GhattiEsther Yoon Grisel J Lopez Debra Ehrlich Silvina G Horovitz

Published in: Journal of neurology (2022)

Our results demonstrate significant cortical thinning in PD patients independent of genotype in superior parietal and postcentral regions when compared to the controls. They highlight the impact of GBA1 variants on cortical thickness in the parietal cortex. Finally, they suggest that recently diagnosed PD patients with N370S variants have a higher cortical thickness and increased active neurodegeneration when compared to PD patients without GBA1 mutations and PD patients with E326K or T369M variants.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
copy number
prognostic factors
high resolution
working memory
gene expression
photodynamic therapy
patient reported