Podocyte and tubular involvement in AngioJet-induced kidney injury.
Raquel EsterasPablo Cannata-OrtizMarta Del Palacio-TamaritMelania Guerrero-HueCristina García-CaballeroJesús EgidoJavier GimenoAlberto OrtizCarolina Gracia-IguacelJuan Antonio MorenoPublished in: Clinical kidney journal (2019)
The AngioJet technique combines localized thrombolysis and percutaneous mechanical thrombectomy (PMT). However, PMT may cause acute kidney injury (AKI), which has been ascribed to severe mechanical haemolysis, although no renal biopsies have been reported. We now report the first renal biopsy in a patient with AKI following PMT. There is histological evidence of haemoglobin (Hb)-induced tubular injury and podocyte stress characterized by intracellular Hb and staining for ferritin and hemo-oxygenase-1, suggestive of an adaptive response to oxidative stress. This confirms that Hb is involved in kidney cell injury and supports the existence of several different kidney cellular targets.
Keyphrases
- high glucose
- acute kidney injury
- endothelial cells
- diabetic rats
- oxidative stress
- ultrasound guided
- cardiac surgery
- pulmonary embolism
- drug induced
- single cell
- fine needle aspiration
- case report
- minimally invasive
- signaling pathway
- dna damage
- mesenchymal stem cells
- diabetic nephropathy
- reactive oxygen species
- ischemia reperfusion injury
- flow cytometry