A Nrf2-OSGIN1&2-HSP70 axis mediates cigarette smoke-induced endothelial detachment: implications for plaque erosion.
Sandro SattaRobert BealRhys SmithXing LuoGlenn R FerrisAlex Langford-SmithJack TeasdaleTom Tanjeko AjimeJef SerréGeorgina HazellGraciela Sala NewbyJason L JohnsonSvitlana KurinnaMartin J HumphriesGhislaine Gayan-RamirezPeter LibbyHans DegensBo YuThomas JohnsonYvonne AlexanderHaibo JiaAndrew C NewbyStephen J WhitePublished in: Cardiovascular research (2023)
We identified a novel Nrf2-OSGIN1&2-HSP70 axis that regulates endothelial adhesion, elevated GDF15 and HSP70 as biomarkers for plaque erosion in patients who smoke, and two therapeutic targets that offer the potential for reducing the risk of plaque erosion.