Small extracellular vesicles derived from adipose mesenchymal stem cells alleviate intestinal fibrosis by inhibiting the FAK/Akt signaling pathway via MFGE8.

Zhizhong XiongXianzhe LiMinghao XieJianping GuoShi YinDayin HuangLongyang JinCaiqin WangFengxiang ZhangChaobin MaoHuaxian ChenDandong LuoHaijie TangXijie ChenLei Lian

Published in: Journal of gastroenterology (2024)

MFGE8-containing AMSC-sEVs attenuate intestinal fibrosis, partly through FAK/Akt pathway inhibition.

Keyphrases

signaling pathway
mesenchymal stem cells
pi k akt
induced apoptosis
epithelial mesenchymal transition
cell migration
cell proliferation
adipose tissue
umbilical cord
bone marrow
type diabetes
cell therapy
metabolic syndrome
oxidative stress