Effects of tacrolimus intrapatient variability and CYP3A5 polymorphism on the outcomes of pediatric kidney transplantation.
Jin Sun ChoiHyun-Min KoHyo Kee KimChris Tae Young ChungAhram HanSeung-Kee MinJongwon HaHee Gyung KangIl-Soo HaSang-Il MinPublished in: Pediatric transplantation (2022)
The IPV of Tac had a significant impact on dnDSA development, occurrence of acute TCMR, and graft failure in pediatric patients who received renal transplantation. CYP3A5 expressors with high IPV of Tac showed worse outcomes, while the CYP3A5 polymorphism had no impact on IPV of Tac.