Effects of tacrolimus intrapatient variability and CYP3A5 polymorphism on the outcomes of pediatric kidney transplantation.

Jin Sun Choi Hyun-Min Ko Hyo Kee Kim Chris Tae Young Chung Ahram Han Seung-Kee Min Jongwon Ha Hee Gyung Kang Il-Soo Ha Sang-Il Min

Published in: Pediatric transplantation (2022)

The IPV of Tac had a significant impact on dnDSA development, occurrence of acute TCMR, and graft failure in pediatric patients who received renal transplantation. CYP3A5 expressors with high IPV of Tac showed worse outcomes, while the CYP3A5 polymorphism had no impact on IPV of Tac.

Keyphrases

kidney transplantation
intimate partner violence
liver failure
respiratory failure
type diabetes
metabolic syndrome
hepatitis b virus
intensive care unit
drug induced
skeletal muscle
weight loss