Single-Cell Profiling Reveals Metabolic Reprogramming as a Resistance Mechanism in BRAF-Mutated Multiple Myeloma.
Johannes Moritz WaldschmidtJake A KloeberPraveen AnandJulia FredeAntonis KokkalisValeriya DimitrovaSayalee PotdarMonica S NairTushara VijaykumarNam Gyu ImAmy Guillaumet-AdkinsNitish ChopraHannah StuartLillian BudanoNoori SotudehGuangwu GuoClemens GrassbergerAndrew J YeeJacob P LaubachPaul Gerard RichardsonKenneth C AndersonNoopur S RajeBirgit KnoechelJens G LohrPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
This study demonstrates that cancer cells have the ability to rapidly adapt to precision treatments through transcriptional state changes, epigenetic adaptation, and metabolic rewiring, thus facilitating the development of refractory disease while simultaneously exposing novel vulnerabilities.