CB1 cannabinoid receptor ligands augment the antidepressant-like activity of biometals (magnesium and zinc) in the behavioural tests.
Sylwia WośkoAnna SerefkoAleksandra SzopaPiotr WlaźAndrzej WróbelAleksandra WlaźJolanta GórskaEwa PoleszakPublished in: The Journal of pharmacy and pharmacology (2018)
The simultaneous modulation of the cannabinoid system and supplementation of magnesium or zinc produce at least additive antidepressant-like effect.