Nuclear Aurora kinase A triggers programmed death-ligand 1-mediated immune suppression by activating MYC transcription in triple-negative breast cancer.

Shu-Lan SunWei ZhouXiaoxi LiFei PengMin YanYajing ZhanFan AnXiaoyan LiYunyong LiuQuentin LiuHaozhe Piao

Published in: Cancer communications (London, England) (2021)

Nuclear AURKA elevated PD-L1 expression via an MYC-dependent pathway and contributed to immune evasion in TNBC. Therapies targeting nuclear AURKA may restore immune responses against tumors.

Keyphrases

immune response
transcription factor
signaling pathway
drug delivery