Endothelial progenitor cells for fabrication of engineered vascular units and angiogenesis induction.
Somayyeh RashidiGhasem BagherpourZahra Abbasi-MalatiNafiseh Didar KhosrowshahiSara Aghakhani ChegeniGolbarg RoozbahaniHamid LotfimehrEmel SokulluReza RahbarghaziPublished in: Cell proliferation (2024)
The promotion of vascularization and angiogenesis in the grafts is a crucial phenomenon in the healing process and tissue engineering. It has been shown that stem cells, especially endothelial progenitor cells (EPCs), can stimulate blood vessel formation inside the engineered hydrogels after being transplanted into the target sites. The incorporation of EPCs into the hydrogel can last the retention time, long-term survival, on-target delivery effects, migration and differentiation into mature endothelial cells. Despite these advantages, further modifications are mandatory to increase the dynamic growth and angiogenesis potential of EPCs in in vitro and in vivo conditions. Chemical modifications of distinct composites with distinct physical properties can yield better regenerative potential and angiogenesis during several pathologies. Here, we aimed to collect recent findings related to the application of EPCs in engineered vascular grafts and/or hydrogels for improving vascularization in the grafts. Data from the present article can help us in the application of EPCs as valid cell sources in the tissue engineering of several ischemic tissues.
Keyphrases
- tissue engineering
- endothelial cells
- stem cells
- vascular endothelial growth factor
- high glucose
- wound healing
- gene expression
- single cell
- physical activity
- electronic health record
- human health
- risk assessment
- gold nanoparticles
- oxidative stress
- mesenchymal stem cells
- extracellular matrix
- bone marrow
- machine learning
- subarachnoid hemorrhage
- big data
- deep learning
- drug induced