Transcriptional profiling of leukocytes in critically ill COVID19 patients: implications for interferon response and coagulation.

Sean E GillClaudia C Dos SantosDavid B O'GormanDavid E CarterEric K PattersonMarat SlessarevClaudio MartinMark DaleyMichael R MillerGediminas CepinskasDouglas D Frasernull null

Published in: Intensive care medicine experimental (2020)

Our findings demonstrate that critically ill COVID19 + patients on day 1 of admission to the ICU display a unique leukocyte transcriptional profile that distinguishes them from COVID19- patients, providing guidance for future targeted studies exploring novel prognostic and therapeutic aspects of COVID19.

Keyphrases

sars cov
gene expression
transcription factor
respiratory syndrome coronavirus

peripheral blood
emergency department
coronavirus disease
intensive care unit

heat shock
cancer therapy
current status
drug delivery

immune response
case control
heat shock protein