PFAS: exploration of neurotoxicity and environmental impact.
Mrunal NannawareNeelaambhigai MayilswamyBalasubramanian KPublished in: Environmental science and pollution research international (2024)
Per- and polyfluoroalkyl substances (PFAS) are widespread contaminants stemming from various industrial and consumer products, posing a grave threat to both human health and ecosystems. PFAS contamination arises from multiple sources, including industrial effluents, packaging, and product manufacturing, accumulating in plants and impacting the food chain. Elevated PFAS levels in water bodies pose significant risks to human consumption. This review focuses on PFAS-induced neurological effects, highlighting disrupted dopamine signalling and structural neuron changes in humans. Animal studies reveal apoptosis and hippocampus dysfunction, resulting in memory loss and spatial learning issues. The review introduces the BKMR model, a machine learning technique, to decipher intricate PFAS-neurotoxicity relationships. Epidemiological data underscores the vulnerability of young brains to PFAS exposure, necessitating further research. Stricter regulations, industry monitoring, and responsible waste management are crucial steps to reduce PFAS exposure.
Keyphrases
- human health
- risk assessment
- climate change
- machine learning
- heavy metals
- drinking water
- wastewater treatment
- oxidative stress
- endothelial cells
- big data
- genome wide
- cell death
- dna methylation
- artificial intelligence
- gene expression
- endoplasmic reticulum stress
- healthcare
- metabolic syndrome
- electronic health record
- brain injury
- sewage sludge
- social media
- cerebral ischemia
- data analysis
- anaerobic digestion