Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha.

Yasuko NagasakaMartin WeplerRobrecht ThoonenPatrick Y SipsKaitlin AllenJan A GrawVincent YaoSara M BurnsStefan MuensterPeter BrouckaertKeith MillerKen SoltEmmanuel S BuysFumito IchinoseWarren M Zapol

Published in: BMC anesthesiology (2017)

Congenital deficiency of GC-1α abolished the ability of sevoflurane anesthesia to increase cGMP levels in the whole brain, and increased the concentration of sevoflurane required to induce LORR. Impaired NO-cGMP signaling raises the threshold for producing sevoflurane-induced unconsciousness in mice.

Keyphrases

nitric oxide
high fat diet induced
protein kinase
high glucose
white matter
diabetic rats
resting state
metabolic syndrome
insulin resistance
skeletal muscle