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Novel antibody against low-n oligomers of tau protein promotes clearance of tau in cells via lysosomes.

Ram Reddy ChandupatlaAndrew FlatleyRegina FeederleEva-Maria MandelkowSenthilvelrajan Kaniyappan
Published in: Alzheimer's & dementia (New York, N. Y.) (2020)
Novel low-n tau oligomer specific monoclonal antibody inhibits Tau oligomerization in cells and promotes toxic tau clearance.
Keyphrases
  • cerebrospinal fluid
  • induced apoptosis
  • monoclonal antibody
  • cell cycle arrest
  • endoplasmic reticulum stress
  • cell death
  • signaling pathway
  • oxidative stress
  • cell proliferation
  • binding protein