Ligand-free 99m Tc-polyurea dendrimer complexes: nanoradiotheranostics targeting ovarian cancer.
Adriana CruzRita F PiresPaula RaposinhoCélia FernandesAntónio PauloVasco D B BonifácioPublished in: Chemical communications (Cambridge, England) (2024)
A folic acid-targeted polyurea (PURE) dendrimer was easily radiolabelled with Technetium-99m ( 99m Tc-PURE G4 -FA 2 ) avoiding the use of additional ligands and bioconjugation chemistry. This straightforward strategy is enabled in PURE dendrimers due to their favourable surface terminal groups configuration, showing coordination capabilities and turning these biodendrimers into attractive platforms for nanoradiotheranostics.