Probiotics ameliorate IgA nephropathy by improving gut dysbiosis and blunting NLRP3 signaling.

Jiaxing TanLingqiu DongZheng JiangLi TanXinyao LuoGaiqin PeiAiya QinZhengxia ZhongXiang LiuYi TangWei Qin

Published in: Journal of translational medicine (2022)

Supplementation with probiotics mainly containing Bifidobacterium could markedly improve gut dysbiosis in IgAN. Moreover, both probiotics and their SCFA metabolites could attenuate the clinicopathological manifestations of IgAN by inhibiting the NLRP3/ASC/Caspase 1 signaling pathway. Therefore, probiotics have potential as an adjunctive therapy for IgAN.

Keyphrases

signaling pathway
nlrp inflammasome
induced apoptosis
cell death
ms ms
pi k akt
cell proliferation
risk assessment