Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC.
Francesca LupoFrancesco PezziniDavide PasiniElena FioriniAnnalisa AdamoLisa VeghiniMichele BevereCristina FrusteriPietro DelfinoSabrina D'agostoSilvia AndreaniGeny PiroAntonia MalinovaTian WangFrancesco De SanctisRita Teresa LawlorChang-Il HwangCarmine CarboneIvano AmelioPeter BaileyVincenzo BronteDavid A TuvesonAldo ScarpaStefano UgelVincenzo CorboPublished in: Gut (2024)
Here, we show that SEMA3A is a stress-sensitive locus that promotes the malignant phenotype of basal-like PDAC through both cell-intrinsic and cell-extrinsic mechanisms.