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Clinical heterogeneity of hyperinsulinism due to HNF1A and HNF4A mutations.

Joanna Yuet-Ling TungKara BoodhansinghCharles A StanleyDiva D De León
Published in: Pediatric diabetes (2018)
Given the heterogeneous clinical phenotypes of HNF1A- and HNF4A-HI, all children with transient, diazoxide-responsive HI without clear history of perinatal stress, should be screened for HNF1A and HNF4A mutations as it predicts the clinical course and affects the subsequent management plan.
Keyphrases
  • nuclear factor
  • toll like receptor
  • pregnant women
  • single cell
  • immune response
  • drug delivery
  • stress induced
  • brain injury