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Novel adjuvant dendritic cell therapy with transfection of heat-shock protein 70 messenger RNA for patients with hepatocellular carcinoma: a phase I/II prospective randomized controlled clinical trial.

Hiroto Matsui MatsuiShoichi HazamaMasao NakajimaMing XuSatoshi MatsukumaYukio TokumitsuYoshitaro ShindoShinobu TomochikaShin YoshidaMichihisa IidaNobuaki SuzukiShigeru TakedaShigefumi YoshinoTomio UenoMasaaki OkaHiroaki Nagano
Published in: Cancer immunology, immunotherapy : CII (2020)
The HSP70 mRNA-transfected DC therapy was performed safely as an adjuvant therapy. The prognosis of HSP70-expressing HCC cases could be expected to improve with this therapy.
Keyphrases
  • heat shock protein
  • dendritic cells
  • heat shock
  • early stage
  • immune response
  • regulatory t cells
  • oxidative stress
  • bone marrow
  • binding protein
  • wild type