In-depth immune cellular profiling reveals sex-specific associations with frailty.

Leonard Daniël SamsonA Mieke H BootsJosé A FerreiraH Susan J PicavetLia G H de RondMary-Lène de Zeeuw-BrouwerW M Monique VerschurenAnne-Marie BuismanPeter Engelfriet

Published in: Immunity & ageing : I & A (2020)

In-depth immune cellular profiling revealed consistent associations of frailty with elevated numbers of myeloid cell subpopulations in both men and women. Furthermore, additional associations were found between frailty and lower numbers of some T cell subpopulations, in women only. Thus, our study indicates sex-specific associations of immune subpopulations with frailty. We hope that our study will prompt further investigation into the sex-specific immune mechanisms associated with the development of frailty.

Keyphrases

single cell
community dwelling
stem cells
polycystic ovary syndrome
pregnant women
adipose tissue
metabolic syndrome
cell therapy