Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer.

Nadia Boufaied Paolo Chetta Tarek Hallal Stefano Cacciatore Daniela Lalli Carole Luthold Kevin Homsy Eddie Luidy Imada Sudeepa Syamala Cornelia Photopoulos Anna Di Matteo Anna de Polo Alessandra Maria Storaci Ying Huang Francesca Giunchi Patricia A Sheridan Gregory A Michelotti Quang-De Nguyen Xin Zhao Yang Liu Elai Davicioni Daniel E Spratt Simone Sabbioneda Giovanni Maga Lorelei A Mucci Claudia Ghigna Luigi Marchionni Lisa M Butler Leigh Ellis Francois Bordeleau Massimo Loda Valentina Vaira David P Labbé Giorgia Zadra

Published in: Cancer research (2024)

Lactate accumulation driven by high-fat diet and MYC reprograms the tumor microenvironment and promotes prostate cancer progression, supporting the potential of lactate as a biomarker and therapeutic target in prostate cancer. See related commentary by Frigo, p. 1742.

Keyphrases

high fat diet
prostate cancer
radical prostatectomy
insulin resistance
adipose tissue
transcription factor
metabolic syndrome
drug induced