Phase 2 study of glucarpidase in patients with delayed methotrexate elimination after high-dose methotrexate therapy.

Atsushi OgawaHiroshi KawamotoJunichi Hara Atsushi KikutaChitose OgawaHiroaki HiragaKenichi YoshimuraKazunari MiyairiReiko OmoriTokihiro RoYuna KameiToshimi Kimura

Published in: Cancer chemotherapy and pharmacology (2024)

Glucarpidase showed an effect of reducing plasma MTX concentration in Japanese patients with DME as that observed in a previous US study, confirming its favorable safety and tolerability.

Keyphrases

high dose
stem cell transplantation
open label
low dose
double blind
clinical trial
stem cells
mesenchymal stem cells
study protocol
replacement therapy