Reverse electromechanical modelling of diastolic dysfunction in spontaneous hypertensive rat after sacubitril/valsartan therapy.

Yen-Ling Sung Ting-Tse Lin Jhen-Yang Syu Hung-Jui Hsu Kai-Yuan Lin Yen-Bin Liu Shien-Fong Lin

Published in: ESC heart failure (2020)

In conclusion, synergistic blockade of the neprilysin and the renin-angiotensin system by SV in SHRs results in KCNN2-associated electrical remodelling in ventricle, which stabilizes electrical dynamics and attenuates arrhythmogenesis.

Keyphrases

blood pressure
ejection fraction
oxidative stress
left ventricular
pulmonary hypertension
pulmonary artery
mitral valve
cancer therapy
congenital heart disease
coronary artery
mesenchymal stem cells
replacement therapy