Physiopathology and genetics in aspirin-exacerbated respiratory disease.

Gandhi Fernando Pavón-Romero Fernando Ramírez-Jiménez Marco Alejandro Roldán-Alvarez Luis Manuel Terán Ramcés Falfan-Valencia

Published in: Experimental lung research (2017)

Genetic association research in AERD has evaluated studies of SNPs in metabolic pathways related to arachidonic acid. Recently, whole genome analysis strategies have allowed the detection of new genetic variants that were previously not considered. Furthermore, these studies have identified SNPs that are associated with inflammatory processes, which could serve as diagnostic markers or predictors of the therapeutic response.

Keyphrases

genome wide
case control
low dose
dna methylation
oxidative stress
cardiovascular events
copy number
loop mediated isothermal amplification
cardiovascular disease
gene expression
antiplatelet therapy
label free
coronary artery disease
drug induced
sensitive detection