Genetic Influences on the Amount of Cell Death in the Neural Tube of BXD Mice Exposed to Acute Ethanol at Midgestation.
Emilie T ThébergeJessica A BakerCandis DuboseJulia K BoyleKristina BalceDan GoldowitzKristin M HamrePublished in: Alcoholism, clinical and experimental research (2019)
These studies demonstrate that the levels of EtOH-induced cell death occur in strain- and region-dependent manners. Novel QTLs on mouse Chr4 and Chr14 were identified that modulate the differential sensitivity to EtOH-induced apoptosis in the embryonic brainstem. The genes underlying these QTLs could identify novel molecular pathways that are critical in this phenotype.
Keyphrases
- cell death
- induced apoptosis
- endoplasmic reticulum stress
- oxidative stress
- genome wide
- signaling pathway
- drug induced
- diabetic rats
- cell cycle arrest
- liver failure
- high glucose
- respiratory failure
- high fat diet induced
- type diabetes
- dna methylation
- case control
- endothelial cells
- single molecule
- cell proliferation
- metabolic syndrome
- adipose tissue
- skeletal muscle
- genome wide identification