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Biases in arginine codon usage correlate with genetic disease risk.

Katharina V SchulzeNeil A HanchardMichael F Wangler
Published in: Genetics in medicine : official journal of the American College of Medical Genetics (2020)
Our findings indicate that genes utilizing CGN arginine codons rather than AGG or AGA are more likely to underlie single-gene disorders, particularly for dominant phenotypes, and thus constitute candidate genes for the study of human genetic disease.
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