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Intratumoral T-cell and B-cell receptor architecture associates with distinct immune tumor microenvironment features and clinical outcomes of anti-PD-1/L1 immunotherapy.

Aimilia SchinaZsofia SztupinszkiInge Marie SvaneZoltan SzallasiGöran JönssonMarco Donia
Published in: Journal for immunotherapy of cancer (2023)
Overall, these data indicate a currently unexplored immunological role of intratumoral B-cells associated with BCR diversity and antibody responses but independent of classical anticancer T-cells intratumoral activities.
Keyphrases
  • acute lymphoblastic leukemia
  • electronic health record
  • tyrosine kinase
  • chronic myeloid leukemia