Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice.
Matthew McMillinStephanie GrantGabriel FramptonAnca D PetrescuElaina WilliamsBrandi JeffersonAlison ThomasAnkita BrahmaroutuSharon DeMorrowPublished in: Journal of neuroinflammation (2019)
Increased circulating TGFβ1 following acute liver failure results in activation of neuronal TGFβR2 signaling, driving neuroinflammation and neurological decline during AOM-induced HE.
Keyphrases
- liver failure
- transforming growth factor
- hepatitis b virus
- cerebral ischemia
- traumatic brain injury
- lipopolysaccharide induced
- epithelial mesenchymal transition
- lps induced
- spinal cord
- cognitive impairment
- drug induced
- high glucose
- early onset
- type diabetes
- subarachnoid hemorrhage
- spinal cord injury
- inflammatory response
- adipose tissue
- skeletal muscle
- high fat diet induced
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation