Farnesoid X receptor alpha ligands inhibit HDV in vitro replication and virion infectivity.

Anne-Flore Legrand Julie Lucifora Benoît Lacombe Camille Ménard Maud Michelet Adrien Foca Pauline Abrial Anna Salvetti Michel Rivoire Vincent Lotteau David Durantel Patrice Andre Christophe Ramière

Published in: Hepatology communications (2023)

FXR ligands both inhibit directly (ie, independently of anti-HBV activity) and indirectly (ie, dependently of anti-HBV activity) the replication, secretion, and infectivity of HDV. The overall anti-HDV activity was superior to that obtained with interferon-α, highlighting the therapeutic potential of FXR ligands in HDV-infected patients.

Keyphrases

hepatitis b virus
liver failure
binding protein
immune response