A novel aqueous dimethyl trisulfide formulation is effective at low doses against cyanide toxicity in non-anesthetized mice and rats.

D S Lippner D M HildenbergerM O RhoomesJessica N WinbornH DixonJ McDonoughG A Rockwood

Published in: Clinical toxicology (Philadelphia, Pa.) (2021)

IM treatment with 10% DMTS improves survival and clinical outcomes in non-anesthetized rodent models of acute CN toxicity. Additionally, the use of an SC KCN delayed-treatment model in rats is advised to assess the performance of a candidate CN countermeasure in a more realistic exposure/treatment scenario.

Keyphrases

oxidative stress
drug delivery
lymph node metastasis
squamous cell carcinoma
liver failure
intensive care unit
metabolic syndrome
respiratory failure
mechanical ventilation
oxide nanoparticles