Modelling the association between COVID-19 transmissibility and D614G substitution in SARS-CoV-2 spike protein: using the surveillance data in California as an example.

Shi ZhaoJingzhi LouLirong CaoHong ZhengMarc K C ChongZigui ChenBenny C Y ZeePaul K S ChanMaggie H Wang

Published in: Theoretical biology & medical modelling (2021)

Our findings show a link between the molecular-level mutation activity of SARS-CoV-2 and population-level transmission of COVID-19 to provide further evidence for a positive association between the D614G substitution and Rt. Future studies exploring the mechanism between SARS-CoV-2 mutations and COVID-19 infectivity are warranted.

Keyphrases

sars cov
respiratory syndrome coronavirus
coronavirus disease
public health
current status
big data
amino acid
artificial intelligence
small molecule
deep learning
case control