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Scratching damages tight junctions through the Akt-claudin 1 axis in atopic dermatitis.

X Q HuY TangY JuX Y ZhangJ J YanC M WangY YangC ZhuZ X TangY ZhouGuang Yu
Published in: Clinical and experimental dermatology (2020)
The results reveal the underlying mechanism of tight junction damage promoted by scratching in the itch-scratch cycle of AD, and opens a new avenue to pruritus management in AD, through Akt antagonists.
Keyphrases
  • atopic dermatitis
  • blood brain barrier
  • signaling pathway
  • cell proliferation
  • oxidative stress
  • single molecule
  • genome wide
  • single cell
  • gene expression