Scratching damages tight junctions through the Akt-claudin 1 axis in atopic dermatitis.
X Q HuY TangY JuX Y ZhangJ J YanC M WangY YangC ZhuZ X TangY ZhouGuang YuPublished in: Clinical and experimental dermatology (2020)
The results reveal the underlying mechanism of tight junction damage promoted by scratching in the itch-scratch cycle of AD, and opens a new avenue to pruritus management in AD, through Akt antagonists.