Azithromycin resistance in Escherichia coli and Salmonella from food-producing animals and meat in Europe.
Mirena IvanovaArmen OvsepianPimlapas LeekitcharoenphonAnne Mette SeyfarthHanne MordhorstSaria OtaniSandra Koeberl-JelovcanMihail MilanovGordan KompesMaria LiapiTomáš ČernýCamilla Thougaard VesterAgnès Perrin-GuyomardJens André HammerlMirjam GrobbelEleni ValkanouSzilárd JánosiRosemarie SloweyPatricia AlbaVirginia CarforaJelena AvsejenkoAsta PereckieneDominique ClaudeRenato ZerafaKees T VeldmanCécile BolandCristina Garcia-GraellsPierre WattiauPatrick ButayeMagdalena ZającAna AmaroLurdes ClementeAngela M VaduvaLuminita-Maria RomascuNicoleta-Manuela MilitaAndrea MojžišováIrena ZdovcMaria Jesús Zamora EscribanoCristina De Frutos EscobarGudrun OvereschChristopher TealeGuy H LoneraganBeatriz GuerraPierre Alexandre BeloeilAmanda M V BrownRene S HendriksenValeria BortolaiaJette Sejer KjeldgaardPublished in: The Journal of antimicrobial chemotherapy (2024)
Diverse azithromycin resistance genes were detected in E. coli and Salmonella from food-producing animals and meat in Europe. Azithromycin resistance genes mef(C)-mph(G) and erm(42) appear to be emerging primarily in porcine E. coli isolates. The identification of distinct mph(A) operon structures in susceptible and resistant isolates increases the predictive power of WGS-based methods for in silico detection of azithromycin resistance in Enterobacterales.