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Subcellular stoichiogenomics reveal cell evolution and electrostatic interaction mechanisms in cytoskeleton.

Yu-Juan ZhangChengxu ZhuYiran DingZheng-Wen YanGong-Hua LiYang LanJian-Fan WenBin Chen
Published in: BMC genomics (2018)
This study creates a blueprint of subcellular stoichiogenomic characteristics, and explains that charged AAs of the cytoskeleton increased greatly in evolution, which offer material basis for the eukaryotic cytoskeletal proteins to act in two ways of electrostatic interactions, and further perform their activation, binding/association and complex formation.
Keyphrases
  • single cell
  • molecular dynamics simulations
  • genome wide
  • cell therapy
  • stem cells
  • mesenchymal stem cells
  • transcription factor
  • bone marrow