The RIVET RCT: Rifamycin SV MMX improves muscle mass, physical function, and ammonia in cirrhosis and minimal encephalopathy.

Jasmohan Singh BajajAndrew FaganEdith A GavisTravis MouselMary L GallagherPuneet PuriMichael FuchsBrian C DavisPhillip B HylemonHuiping ZhouVishwadeep AhluwaliaRobert CadrainMasoumeh SikaroodiPatrick M Gillevet

Published in: Hepatology communications (2024)

RiVM is well tolerated in patients with MHE with changes in stool microbial composition and function, ammonia, inflammation, brain oxidative stress, and sarcopenia-related parameters without improvement in cognition. RiVM modulates the gut-brain axis and gut-muscle axis in cirrhosis.

Keyphrases

oxidative stress
white matter
resting state
skeletal muscle
functional connectivity
room temperature
dna damage
anaerobic digestion
cerebral ischemia
microbial community
ischemia reperfusion injury
early onset
mild cognitive impairment
induced apoptosis
signaling pathway
blood brain barrier