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Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexes.

Iliana SotoMary CouvillionKatja G HansenErik McShaneJ Conor MoranAntoni BarrientosL Stirling Churchman
Published in: Genome biology (2022)
Based on our findings, we propose that human OXPHOS complexes are synthesized proportionally to each other, with mitonuclear balance relying on the regulation of OXPHOS subunit translation across cellular compartments, which may represent a proteostasis vulnerability.
Keyphrases
  • endothelial cells
  • induced pluripotent stem cells
  • oxidative stress