Germline mutations in PPFIBP2 are associated with lethal prostate cancer.
Yishuo WuHongjie YuSiqun Lilly ZhengBingjian FengAshley L KapronRong NaJulie L BoyleSameep ShahZhuqing ShiCharles M EwingKathleen E WileyJun LuoPatrick C WalshHerbert Ballentine CarterBrian T HelfandKathleen A CooneyJianfeng XuWilliam B IsaacsPublished in: The Prostate (2018)
While larger studies are needed, germline mutations in a novel gene, PPFIBP2, differentiated risk for lethal PCa from low-risk cases and were associated with shorter survival times after diagnosis.