Germline mutations in PPFIBP2 are associated with lethal prostate cancer.

Yishuo WuHongjie YuSiqun Lilly ZhengBingjian FengAshley L KapronRong NaJulie L BoyleSameep ShahZhuqing ShiCharles M EwingKathleen E WileyJun LuoPatrick C WalshHerbert Ballentine CarterBrian T HelfandKathleen A CooneyJianfeng Xu William B Isaacs

Published in: The Prostate (2018)

While larger studies are needed, germline mutations in a novel gene, PPFIBP2, differentiated risk for lethal PCa from low-risk cases and were associated with shorter survival times after diagnosis.

Keyphrases

prostate cancer
dna repair
radical prostatectomy
copy number
dna damage
case control
gene expression
dna methylation