Motives, frequency, predictors and outcomes of MRA discontinuation in a real-world heart failure population.
Anna Jonsson HolmdahlGustav WessbergHelena NorbergAdrian SöderströmFredrik ValhamEllinor BergdahlKrister LindmarkPublished in: Open heart (2023)
Half of all patients with HFrEF initiated on MRA discontinued the treatment. A substantial number of patients discontinued MRA without meeting the guideline-recommended levels of eGFR and S-potassium where mild to moderate hyperkalaemia seems to be the most decisive predictor. Further, MRA discontinuation was associated with increased adjusted risk of all-cause mortality.
Keyphrases
- contrast enhanced
- heart failure
- end stage renal disease
- small cell lung cancer
- ejection fraction
- chronic kidney disease
- newly diagnosed
- magnetic resonance imaging
- peritoneal dialysis
- prognostic factors
- epidermal growth factor receptor
- magnetic resonance
- tyrosine kinase
- metabolic syndrome
- atrial fibrillation
- insulin resistance
- skeletal muscle
- cardiac resynchronization therapy
- smoking cessation