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High-resolution melting assay for rapid, simultaneous detection of JAK2 , MPL and CALR variants.

Christopher M SandeGuang YangAyman MohamedBen L LegendreDanielle PionStephanie L FerroKate GrimmKojo S J Elenitoba-Johnson
Published in: Journal of clinical pathology (2023)
These studies demonstrate the exquisite accuracy, sensitivity and specificity of the HRM-based HemeScreen MPN assay, which serves as a powerful, clinically applicable platform for rapid, simultaneous detection of clinically relevant, somatic disease variants.
Keyphrases
  • loop mediated isothermal amplification
  • high resolution
  • copy number
  • high throughput
  • sensitive detection
  • label free
  • mass spectrometry
  • dna methylation
  • genome wide
  • case control
  • single cell
  • quantum dots