Circulating cell free DNA during definitive chemo-radiotherapy in non-small cell lung cancer patients - initial observations.

Lotte NygårdLise B AhlbornGitte F PerssonDineika ChandranandaJonathan W LangerBarbara M FischerSeppo W LangerMigle GabrielaiteAndreas KjærNitzan RosenfeldFlorent MouliereOlga ØstrupIvan R VogeliusSøren M Bentzen

Published in: PloS one (2020)

Concentrations of cfDNA remain stable during the first 2 hours after an RT fraction. However, based on the sWGS profiles, ctDNA represented only a minor fraction of cfDNA in this group of patients. The detection sensitivity of genomic alterations in ctDNA strongly increases by applying size selection.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
locally advanced
early stage
radiation therapy
squamous cell carcinoma
photodynamic therapy
gene expression
patient reported outcomes
rectal cancer
cancer therapy
patient reported