SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase.

Augustin LatourteSarah JaulerryAlice CombierChahrazad CherifiYohan JouanThierry GrangeJulien DaligaultHang-Korng EaMartine Cohen SolalEric HayPascal Richette

Published in: Annals of the rheumatic diseases (2024)

SerpinA3N protects cartilage against catabolic factors produced by macrophages, including LE. SerpinA3N and LE represent new therapeutic targets to dampen cartilage damage in OA.

Keyphrases

extracellular matrix
knee osteoarthritis
rheumatoid arthritis
signaling pathway
adipose tissue