Kidney biopsy findings in vancomycin-induced acute kidney injury: a pooled analysis.
Ioannis BellosVasilios PergialiotisDespina N PerreaPublished in: International urology and nephrology (2021)
Acute tubular necrosis and tubulointerstitial nephritis represent the main histological patterns of vancomycin-induced acute kidney injury. The presence of fibrosis in the context of interstitial inflammation may be linked to lower recovery rates and worse long-term renal outcomes. A novel cast nephropathy obstructive mechanism has been suggested, necessitating further confirmation. Large-scale studies should define the exact indications of kidney biopsy in cases with suspected vancomycin nephrotoxicity.
Keyphrases
- acute kidney injury
- high glucose
- drug induced
- methicillin resistant staphylococcus aureus
- cardiac surgery
- diabetic rats
- oxidative stress
- ultrasound guided
- endothelial cells
- pulmonary embolism
- staphylococcus aureus
- adipose tissue
- extracorporeal membrane oxygenation
- weight loss
- case control
- acute respiratory distress syndrome
- aortic dissection
- glycemic control