ABCB1 polymorphism predicts the toxicity and clinical outcome of lung cancer patients with taxane-based chemotherapy.

Jia ZhongZihan GuoLiping FanXinghui ZhaoBingqing ZhaoZhigang CaoLinlin ChengYuanyuan ShiXiaoting LiYanhua ZhangTongtong AnMeina WuYuyan WangMinglei ZhuoJianjie LiXue YangHanxiao ChenBo JiaJun Zhao

Published in: Thoracic cancer (2019)

ABCB1 mutation is associated with higher neurotoxicity of taxane-based chemotherapy. It also predicts shorter PFS for NSCLC in paclitaxel-based treatment.

Keyphrases

locally advanced
small cell lung cancer
chemotherapy induced
squamous cell carcinoma
advanced non small cell lung cancer
replacement therapy
brain metastases
epidermal growth factor receptor
smoking cessation