NAAA is dysregulated in colorectal cancer patients and its inhibition reduces experimental cancer growth.

Barbara RomanoEster PaganoFabio Arturo IannottiFabiana PiscitelliVincenzo BrancaleoneGiuseppe LucarielloMaria Francesca NanìFerdinando FiorinoRosa SparacoGiovanna VanacoreFederica Di TellaDonatella CiciaRuggero LionettiAlexandros MakriyannisMichael MalamasMarcello De LucaGiovanni ApreaMaria D'ArmientoRaffaele CapassoBernardo SbarroTommaso VenneriVincenzo Di MarzoFrancesca BorrelliAngelo A Izzo

Published in: British journal of pharmacology (2021)

Our results provide unprecedented data on the functional importance of NAAA in CRC progression and its mechanism. We propose this enzyme as a valid drug target for the treatment of CRC growth and development.

Keyphrases

papillary thyroid
electronic health record
emergency department
big data
squamous cell carcinoma
squamous cell
young adults
adverse drug
deep learning