Characteristics of Ebola Virus Disease Survivor Blood and Semen in Liberia: Serology and Reverse Transcription Polymerase Chain Reaction (RT-PCR).
Aaron D KofmanSusanne LindermanKaihong SuLawrence J PurpuraElizabeth ErvinShelley BrownMaria Morales-BetoulleJames GrazianoDeborah L CannonJohn D KlenaRodel Desamu-ThorpeJohn FankhauserRomeo OroneSoka MosesUriah GlayboMoses MassaquoiTolbert NyenswahStuart T NicholJomah KollieArmah KiawuEdna FreemanGiovanni GiahHenry TonyMylene FaikaiMary JawaraKuku KamaraSamuel KamaraBenjamin FlowersKromah MohammedDavid ChiribogaDesmond E WilliamsSteven H HinrichsRafi AhmedBenjamin VonhmPierre E RollinMary J ChoiPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
The blood of EVD survivors, collected when they did not have symptoms meeting the case definition for acute or relapsed EVD, is unlikely to pose a risk for EBOV transmission. We identified 1 IgM/IgG negative participant who had PBMCs that produced anti-EBOV-specific antibodies upon stimulation. Immunogenicity following acute EBOV infection may exist along a spectrum, and absence of antibody response should not be exclusionary in determining an individual's status as a survivor of EVD.