Outcomes of Percutaneous Coronary Intervention for In-Stent Restenosis Versus De Novo Lesions: A Meta-Analysis.
Ayman ElbadawiAlexander T DangIngy MahanaMohammed ElzeneiniFernando AlfonsoSubhash BanerjeeDharam J KumbhaniAkram Y ElgendyGary S MintzPublished in: Journal of the American Heart Association (2023)
Background In-stent restenosis (ISR) is commonly encountered even in the era of contemporary percutaneous coronary intervention (PCI). There is a paucity of data on the comparative outcomes of PCI for ISR lesions versus de novo lesions. Methods and Results An electronic search was conducted for MEDLINE, Cochrane, and Embase through August 2022 for studies comparing the clinical outcomes after PCI for ISR versus de novo lesions. The primary outcome was major adverse cardiac events. Data were pooled using a random-effects model. The final analysis included 12 studies, with a total of 708 391 patients, of whom 71 353 (10.3%) underwent PCI for ISR. The weighted follow-up duration was 29.1 months. Compared with de novo lesions, PCI for ISR was associated with a higher incidence of major adverse cardiac events (odds ratio [OR], 1.31 [95% CI, 1.18-1.46]). There was no difference on a subgroup analysis of chronic total occlusion lesions versus none ( P interaction =0.69). PCI for ISR was associated with a higher incidence of all-cause mortality (OR, 1.03 [95% CI, 1.02-1.04]), myocardial infarction (OR, 1.20 [95% CI, 1.11-1.29]), target vessel revascularization (OR, 1.42 [95% CI, 1.29-1.55]), and stent thrombosis (OR, 1.44 [95% CI, 1.11-1.87]), but no difference in cardiovascular mortality (OR, 1.04 [95% CI, 0.90-1.20]). Conclusions PCI for ISR is associated with higher incidence of adverse cardiac events compared with PCI for de novo lesions. Future efforts should be directed toward prevention of ISR and exploring novel treatment strategies for ISR lesions.
Keyphrases
- percutaneous coronary intervention
- st segment elevation myocardial infarction
- coronary artery disease
- acute coronary syndrome
- acute myocardial infarction
- antiplatelet therapy
- st elevation myocardial infarction
- coronary artery bypass grafting
- atrial fibrillation
- left ventricular
- risk factors
- coronary artery bypass
- heart failure
- electronic health record
- magnetic resonance imaging
- pulmonary embolism
- computed tomography
- chronic kidney disease
- cardiovascular disease
- clinical trial
- ejection fraction
- emergency department
- type diabetes
- adverse drug
- quality improvement
- patient reported