Epigenetic modulation of neuroblastoma enhances T cell and NK cell immunogenicity by inducing a tumor-cell lineage switch.

Annelisa M CornelEster DunnebachDamon A HofmanSanjukta DasSatyaki SenguptaFemke van den HamJudith WienkeJosephine G M StrijkerDenise A M H van den BeemtAnke H W EssingBianca KoopmansSem A G EngelsVania Lo PrestiCelina S SzantoRani E GeorgeJan J MolenaarSebastiaan van HeeschMiranda P DierselhuisS Nierkens

Published in: Journal for immunotherapy of cancer (2022)

This study indicates the potential of combining (immuno)therapy with HDACi to enhance both T cell-driven and NKcell-driven immune responses in patients with HR-NBL.

Keyphrases

nk cells
immune response
single cell
dna methylation
cell therapy
gene expression
stem cells
dendritic cells
risk assessment
mesenchymal stem cells
climate change
human health
inflammatory response
cell fate
replacement therapy