Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain.
Gabriele CeruttiYicheng GuoPengfei WangManoj S NairYaoxing HuangJian YuLihong LiuPhinikoula S KatsambaFabiana BahnaEswar R ReddemPeter D KwongDavid D HoZizhang ShengLawrence ShapiroPublished in: bioRxiv : the preprint server for biology (2021)
Cryo-EM structure of neutralizing antibody 5-7 in complex with SARS CoV-2 spike5-7 recognizes NTD outside of the previously identified antigenic supersite5-7 binds to a site known to accommodate numerous hydrophobic ligandsStructural basis of 5-7 neutralization tolerance to some variants of concern.