Comprehensive molecular analysis of immortalization hallmarks in thyroid cancer reveals new prognostic markers.
Cristina Montero-CondeLuis Javier Leandro-GarcíaÁngel M Martínez-MontesPaula MartínezFrancisco J MoyaRocío LetónEduardo GilNatalia Martínez-PuenteSonsoles GuadalixMaria Currás-FreixesLaura García-TobarCarles ZafonMireia JordàGarcilaso Riesco-EizaguirrePatricia González-GarcíaMaría MonteagudoRafael Torres-PérezVeronika MancikovaSergio Ruiz-LlorenteManuel Pérez-MartínezGuillermo PitaJuan Carlos GalofréAnna Gonzalez-NeiraAlberto CascónCristina Rodríguez-AntonaDiego MegíasMaría A BlascoEduardo CaleirasSandra Rodríguez-PeralesMercedes RobledoPublished in: Clinical and translational medicine (2022)
Overall, our findings support that telomere shortening leads to a 5p subtelomeric region reorganization, facilitating the transcription and accumulation of alterations at TERT-locus.