Hypertensive Disorders of Pregnancy and Fetal Growth Restriction: Clinical Characteristics and Placental Lesions and Possible Preventive Nutritional Targets.
Daniela Denis Di MartinoLaura AvaglianoEnrico Mario FerrazziFederica FusèVittoria SterpiMarco ParasilitiTamara StampalijaSara ZullinoAntonio FarinaGaetano Pietro BulfamanteMatteo Di MasoFrancesco D'AmbrosiPublished in: Nutrients (2022)
We found a prevalence of placental maternal vascular malperfusion in HDP-FGR and early FGR groups. These lesions were also associated with abnormal, anti-, and angiogenic markers. Conversely HDP-AGA fetus and late FGR presented more heterogeneous placental lesions not severe enough to cause feto-placental Doppler anomalies. These conditions are likely associated with different etiologies, such as maternal pre-pregnancy risk factors for metabolic syndrome. These findings suggest a possible preventive nutritional approach in addition to low-dose aspirin in pregnant women with predisposing factors for HDP-AGA fetuses and late FGR.
Keyphrases
- low dose
- pregnancy outcomes
- metabolic syndrome
- pregnant women
- preterm birth
- birth weight
- blood pressure
- gestational age
- high dose
- risk factors
- early onset
- cardiovascular events
- physical activity
- coronary artery disease
- adipose tissue
- skeletal muscle
- cardiovascular risk factors
- atrial fibrillation
- percutaneous coronary intervention